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Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophicfactor and tropomyosin-related kinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 411-415 doi: 10.1007/s11684-012-0226-2

Abstract: Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-relatedketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat

Keywords： tramadol     ketamine     antidepressant     brain-derived neurotrophic factor     tropomyosin-related kinase B    

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Neurolemma-Injected Xenopus Oocytes: An Innovative Ex Vivo Approach to Study the Effects Review

John Clark, Steve Symington

Engineering 2020, Volume 6, Issue 5,   Pages 515-521 doi: 10.1016/j.eng.2019.10.017

Abstract:

Microtransplantation of rat brain neurolemma into the plasma membrane of Xenopus laevis oocytesIn this review, we show that oocytes injected with adult rat brain neurolemma elicited tetrodotoxin-sensitiveUnder our initial protocols, oocyte health was reduced over time and neurolemma incorporation variedassay to study the toxicodynamic action of pyrethroids on ion channels in their native state using neurolemmafragments prepared from juvenile and adult rat brains.

Keywords： Microtransplantation     Pyrethroids     Rat brain neurolemma     Toxicodynamics     Voltage-sensitive sodium channels    

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Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 264-268 doi: 10.1007/s11684-008-0050-x

Abstract: Domestic application of infrared patch clamp techniques on brain slices is limited.The key of the technique is to prepare high-quality brain slices.paper describes the preparation procedure of brainstem slices and the spontaneous firing properties of ratBy infrared differential interference contrast technique, neurons of rat MVN were visualized directly

Keywords： resistance     infrared     infrared videomicroscopy     depressive     after-hyperpolarization potential    

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Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 70-74 doi: 10.1007/s11684-008-0013-2

Abstract: To investigate the relationship between protein aggregation and delayed neuronal death, we adopted ratBrain ischemia was produced using the 2-vessel occlusion (2VO) model in rats Light microscopy, transmission
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Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured

YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 239-243 doi: 10.1007/s11684-008-0045-7

Abstract: Internal standards are critical for quantitative RNA analyses. Housekeeping genes are often used as internal standards with the assumption that their expression levels remain relatively constant in different experimental conditions. In this study, four commonly used housekeeping genes, Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), ?-actin, 28S rRNA and 18S rRNA were selected to test whether this assumption is tenable under hypoxic conditions. We tested the RNA expression level of these four genes in different hypoxic conditions. Rats subjected to acute hypoxia for 2 hours were used for tissue detection. Primary cultured neural stem cells from E13 fetal rats were treated with 3% O or 10% O for 24 hours for experiments. In both experiments, expression levels of 28S rRNA and 18S rRNA were constant, independent of hypoxia types. However, expression levels of GAPDH and ?-actin were all changed in all kinds of hypoxic conditions. In particular, the mRNA expression level of GAPDH was increased by 43.4% under 3% O hypoxic conditions. These results suggest that 18S rRNA and 28S rRNA are reliable internal controls for comparative analyses of transcription under hypoxia. GAPDH appears particularly unfavorable for this purpose in hypoxic conditions.

Keywords： Glyceraldehyde-3-phosphate dehydrogenase     comparative     constant     unfavorable     independent    

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c-Fos expression in rat brainstem following intake of sucrose or saccharin

Ke Chen, Jianqun Yan, Jinrong Li, Bo Lv, Xiaolin Zhao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 294-301 doi: 10.1007/s11684-011-0144-8

Abstract: To examine whether the activation of brainstem neurons during intake of a sweet tastant is due to orosensory signals or post-ingestive factors, we compared the distribution of c-Fos-like immunoreactivity (c-FLI) in the nucleus of the solitary tract (NST) and parabrachial nucleus (PBN) of brainstem following ingestion of 0.25 M sucrose or 0.005 M saccharin solutions. Immunopositive neurons were localized mainly in the middle zone of the PBN and four rostral-caudal subregions of the NST. Intake of sucrose increased the number of FLI neurons in almost every subnucleus of the PBN (F = 7.610, = 0.023), in addition to the caudal NST at the level of the area postrema (F = 10.777, = 0.003) and the NST intermediate zone (F = 7.193, = 0.014). No significant increase in the number of c-Fos positive neurons was detected in response to saccharin ingestion, although there was a trend towards a modest increase in a few select NST and PBN nuclei. These results suggest that the PBN and NST may be involved in sweet taste perception and modulation of sweet tastant intake, but the significantly enhanced intensity of Fos expression induced by sucrose indicates that PBN/NST neuronal activity is driven by the integrated effects of sweet taste sensation and post-ingestive signals.

Keywords： c-Fos     parabrachial     the nucleus of the solitary tract     sweet tastant     rat    

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A Temporal–Spatial Atlas of Peripheral Nerve Evoked Cortex Potential in Rat: A Novel Testbed to Explorethe Responding Patterns of the Brain to Peripheral Nerves Article

Xiaofeng Yin, Jiuxu Deng, Bo Chen, Bo Jin, Xinyi Gu, Zhidan Qi, Kunpeng Leng, Baoguo Jiang

Engineering 2022, Volume 14, Issue 7,   Pages 147-155 doi: 10.1016/j.eng.2021.04.018

Abstract:

Observing the dynamic progress of the brain in response to peripheral nerve stimulation as a wholemini-invasive orthogonal recording method is developed to observe the overall evoked cortex potential (ECP) in ratbrain.A typical ECP atlas with recognizable waveforms in the rat cortex corresponding to the median, ulnar,Reproducible exciting temporal–spatial progress in the rat brain is obtained and visualized for

Keywords： Peripheral nerve     Brain     Evoked cortex potential     Temporal–spatial     Atlas    

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Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 760-765 doi: 10.1007/s11684-021-0899-5

Abstract: outcomes of patients awaiting lung transplantation (LTx) after the implementation of donation after brain

Keywords： lung transplantation     donation after brain death     waitlist    

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Cooling strategies and transport theories for brain hypothermia resuscitation

LIU Jing

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 32-57 doi: 10.1007/s11708-007-0004-z

Abstract: The brain is one of the most important organs in a biological body whose normal function depends heavilyUnlike skeletal muscles that can survive for hours without oxygen, neuron cells in the brain are easilyThe reason can be attributed to the decreased metabolic requirements of the cold brain tissues, whichallows a longer duration for the brain to endure reduced oxygen delivery.Meanwhile, some future efforts worth pursuing within the area of brain cooling are suggested.

Keywords： mathematical     interruption     hypothermia     metabolic     generation    

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Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract:

This study compared proteome profiles and morphological changes of rat jejunum in response to different

Keywords： Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

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diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulantPlasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 8-14 doi: 10.1007/s11684-011-0109-y

Abstract:

Brain-dead donors have become one of the main sources of organs for transplantation in Western countriesExperimental studies have confirmed the inferior graft survival of livers from brain-dead donors comparedStudies conducted in the past 10 years have shown that brain death is associated with effects on theHowever, whether the decrease in the viability of donor organs is caused by brain death or by the eventsbefore and after brain death remains uncertain.

Keywords： brain death     donor liver    

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A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection

Lichun Zhong

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 367-377 doi: 10.1007/s11684-013-0266-2

Abstract:

This study aimed to modify a chronic ocular hypertension (OHT) rat model to screen for potential compoundsThe OHT rat model was created via the injection of a hypertonic saline solution into the episcleral veins

Keywords： chronic ocular hypertension     intraocular pressure     retinal ganglion cells     neuroprotection     glaucoma    

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Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 842-866 doi: 10.1007/s11684-021-0865-2

Abstract: Considering that subsequent therapies are also affected, all these brain infections cause significant

Keywords： free-living amoebae     central nervous system infection     primary amoebic meningoencephalitis     granulomatous amoebic encephalitis    

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Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: The aim of the present study was to construct the lentiviral RNA interference (RNAi) vector of rat OBRbreducing gene expression were further confirmed by real-time polymerase chain reaction in transfected ratspecifically reduced the expression of OBRb mRNA by approximately 80% compared with controls in transfected ratThe successful construction of rat lentivirus vectors expressing OBRb-specific shRNA may be useful for

Keywords： receptors     leptin     RNA interference     lentivirus vector    

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Title Author Date Type Operation

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophicfactor and tropomyosin-related kinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Journal Article

Neurolemma-Injected Xenopus Oocytes: An Innovative Ex Vivo Approach to Study the Effects

John Clark, Steve Symington

Journal Article

Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Journal Article

Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Journal Article

Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured

YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming

Journal Article

c-Fos expression in rat brainstem following intake of sucrose or saccharin

Ke Chen, Jianqun Yan, Jinrong Li, Bo Lv, Xiaolin Zhao

Journal Article

A Temporal–Spatial Atlas of Peripheral Nerve Evoked Cortex Potential in Rat: A Novel Testbed to Explorethe Responding Patterns of the Brain to Peripheral Nerves

Xiaofeng Yin, Jiuxu Deng, Bo Chen, Bo Jin, Xinyi Gu, Zhidan Qi, Kunpeng Leng, Baoguo Jiang

Journal Article

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Journal Article

Cooling strategies and transport theories for brain hypothermia resuscitation

LIU Jing

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat

Journal Article

The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Journal Article

A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection

Lichun Zhong

Journal Article

Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease

Journal Article

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Journal Article